Horrified passengers can be seen watching on as the two men, one dressed in a red Hawaiian shirt, begin hurling punches at each other from their seats.
The video, which has gone viral since it was posted on Twitter this morning, is believed to have been filmed on a Japanese ANA flight.
It shows the men begin brawling before one of the pair shouts “someone help, this guy’s crazy” after punching him in the back of the head.
An air stewardess helplessly tries to stand between the pair, before one of the men, with his shirt seemingly ripped from his back, makes his way towards the front of the plane.
But more carnage ensues when he returns and begins to square up to his fellow passenger and the two begin brawling once more.
A baby can also be heard crying in the background and horrified passengers can been seen watching on.
The footage was posted by the creator of American based news Twitter account Drama Alert, though it is unclear whether he filmed the video.
It ends before the aftermath of the fight can be seen.
By the end, the man in his seat can be heard begging staff to remove the man he has fought from the plane.
Japan Today reported that a 44-year-old American passenger was charged with assaulting a male employee at Narita International Airport, in Tokyo.
The incident happened just before the plane was due to depart for Los Angeles.
It comes amid a series of controversies for airlines recently, starting with a doctor being beaten by security staff on a United Airlines flight last month.
United Airlines reached a financial settlement with beaten doctor David Dao.
Soon after a shocking video emerged of an American Airlines flight attendant threatening to fight a passenger after the employee allegedly hit a mother with a stroller.
n social media